The TNQ Distinguished Lectures in the Life Sciences

Helen Hobbs

'Genetic Disorders of Dietary Excess: Getting to
the Heart of the Matter'

Series I. 9ᵗʰ Edition.
Hyderabad | Bengaluru | New Delhi

Breakthrough Prize Laureate Helen Hobbs was the 2019 Speaker of the TNQ Distinguished Lectures in the Life Sciences

Dr Helen H. Hobbs, Investigator for the Howard Hughes Medical Institute and Director of the Eugene McDermott Center for Human Growth and Development at the University of Texas Southwestern Medical Center, was the 2019 Speaker of the ninth edition of TNQ Distinguished Lectures in the Life Sciences. She gave lectures in Hyderabad, Bengaluru, and New Delhi.

Professor Hobbs’ work is focussed on searching for genetic factors that contribute to, and protect us from, diseases arising from dietary excess as food has become easily available and human beings more sedentary. In 1999, along with her colleagues, Professor Hobbs established the Dallas Heart Study (DHS) aimed at identifying factors that contribute to coronary heart disease and metabolic disorders. This 3500+ population group study showed that mutations in the protein PCSK9 result in lower levels of low-density lipoprotein (LDL), the cholesterol in the blood that leads to atherosclerosis or the clogging of arteries.

These observations led to the rapid development of two FDA-approved, anti-PCSK9 antibodies for the treatment of hypercholesterolemia and the prevention of coronary atherosclerosis. More recently, Dr Hobbs’ team has identified sequence variations that are associated with the full spectrum of alcoholic and non-alcoholic fatty liver disease (FLD), including steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC).

Dr Hobbs and her team found that mutations in the protein PNPLA3 were strongly linked to this condition. Yet another screen showed that a mutation in TM6SF2 led to an increase in fat content. Dr Hobbs’ team has shown that this protein helps the liver secrete fat into the blood in triglyceride-rich lipoproteins.

Dr Hobbs attended Stanford University and Case Western Reserve Medical School before training in internal medicine at the Columbia-Presbyterian Hospital in New York City, and the University of Texas Southwestern Medical Center in Dallas, Texas

After completing a post-doctoral fellowship in the laboratory of Dr Joseph Goldstein and Dr Michael Brown, she joined the faculty of UT Southwestern. Dr Hobbs was elected to the Institute of Medicine in 2004 and the National Academy of Sciences in 2007.

Awards & Honors

2007

Distinguished Scientist Award, American Heart Association

2012

International Society of Atherosclerosis Prize

2016

Passano Foundation Award (with Jonathan Cohen)

2016

Breakthrough Prize in the
Life Sciences

2018

Fondation Lefoulon-Delalande Grand Prix Award

2009

Harrington Prize for Innovation in Medicine, American Society for Clinical Investigation & Harrington Discovery Institute

Lecture Schedule

LOCATION

Hyderabad:

Savitribai Phule Auditorium University of Hyderabad Campus

DATE

February 11, 2019, 4.30 p.m.

INTRODUCTION BY

Dr Jyotsna Dhawan

Chief Scientist Centre for Cellular & Molecular Biology(CCMB)

Bengaluru:

St. John’s Auditorium
St. John’s Hospital Campus

February 13, 2019, 4.30 p.m.

Dr Anura V. Kurpad

Professor of Physiology
St. John’s Medical College

New Delhi:

All India Council for Technical Education (AICTE) Auditorium JNU Campus

January 22, 2020, 6.00 p.m.

Professor K. VijayRaghavan

Principal Scientific Adviser (PSA)
Government of India

Lecture Schedule

LOCATION

Hyderabad:

Savitribai Phule Auditorium University of Hyderabad Campus

DATE

February 11, 2019, 4.30 p.m.

INTRODUCTION BY

Dr Jyotsna Dhawan

Chief Scientist Centre for Cellular & Molecular Biology(CCMB)

LOCATION

Bengaluru:

St. John’s Auditorium St. John’s Hospital Campus

DATE

February 13, 2019, 4.30 p.m.

INTRODUCTION BY

Dr Anura V. Kurpad

Professor of Physiology St. John’s Medical College

LOCATION

New Delhi:

All India Council for Technical Education (AICTE) Auditorium JNU Campus

DATE

January 22, 2020, 6.00 p.m.

INTRODUCTION BY

Professor K. VijayRaghavan

Principal Scientific Adviser (PSA) Government of India

Other Lectures

2020

Venki Ramakrishnan

My Adventures in the Ribosome

2018

David Anderson

The Neural Circuitry of Sex and Violence

2017

Mary-Claire King

Understanding Inherited Breast and Ovarian Cancer...

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